Effects of Nigella Sativa and Syzygium Cumini Seed Extracts on Blood Glucose Levels in Swiss Albino Mice

Authors

  • Tufael Department of Biochemistry, Ibn Sina Diagnostic and Imaging Center, Dhaka, Bangladesh Author
  • Sayed Eqramul Hasan Bangabandhu Sheikh Mujib Medical College, Faridpur, Bangladesh Author
  • Arafath Jubayer Pathfinder Research and Consultancy Center, Bangladesh Author
  • Khurshida Akter AYAT College of Nursing and Health Sciences, Bangladesh Author
  • Afsana Akter Department of Pharmacy,Gono Bishwabidyalay, Savar, Bangladesh Author
  • Fatema Akter Department of Pharmacy,Gono Bishwabidyalay, Savar, Bangladesh Author
  • Sarder Abdulla Al Shiam St. Francis College, Brooklyn, New York 11201, USA Author
  • Atiqur Rahman Sunny Pathfinder Research and Consultancy Center, Bangladesh. Department of Genetic Engineering and Biotechnology, Shahjalal University of Science and Technology, Bangladesh. Author https://orcid.org/0000-0001-8751-8459

DOI:

https://doi.org/10.60087/jklst.vol2.n3.p62

Keywords:

Nigella Sativa, Syzygium Cumini, Blood Glucose, Albino mice, Bangladesh

Abstract

A Swiss Albino mouse model was used to study the effects of two species that are common in Bangladesh: Nigella Sativa L. and Syzygium Cumini L. The trial looked at how a blend of methanol extracts from Syzygium Cumini L. and Nigella Sativa L. affected blood sugar levels using the oral glucose tolerance test (OGTT). 40 overnight starved mice were divided into eight groups with a 4:1 male to female ratio. After 120 minutes of glucose injection, blood glucose levels were measured using a glucometric method. However, the mean values of the samples that were only treated with high doses of Syzygium Cumini L. (Group 1) and Nigella Sativa L. (Group 2) were 3.92 mmol/l and 3.8 mmol/l, respectively. Group-5 low dose (50 mg/kg) treated mean value was 4.02 mmol/l, group-6 moderate dose (100 mg/kg) treated mean value was 3.7 mmol/l, group-7 poly medium dose (200 mg/kg) treated mean value was 3.38 mmol/l, and group-8 poly high dose (400 mg/kg) treated mean value was 3.12 mmol/l where combined extract formulations were used. The combined formulation of the methanol extract of Nigella Sativa L. (Seed) and Syzygium Cumini L. (Seed) possesses significant oral hypoglycemic activity at different time intervals in the cases when compared to Control mean value, showing that all doses given significantly reduced blood sugar level

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Published

2024-01-13

How to Cite

Tufael, Sayed Eqramul Hasan, Arafath Jubayer, Khurshida Akter, Afsana Akter, Fatema Akter, Sarder Abdulla Al Shiam, & Atiqur Rahman Sunny. (2024). Effects of Nigella Sativa and Syzygium Cumini Seed Extracts on Blood Glucose Levels in Swiss Albino Mice. Journal of Knowledge Learning and Science Technology ISSN: 2959-6386 (online), 2(3), 53-62. https://doi.org/10.60087/jklst.vol2.n3.p62