Transforming Neurological Disease Modeling and Therapy with 3D Bioprinting
DOI:
https://doi.org/10.60087/jklst.v4.n2.011Abstract
Three-dimensional (3D) bioprinting is transforming neuroscience, tissue engineering, and regenerative medicine by enabling the precise fabrication of complex, functional biological structures. This review provides a comprehensive overview of the latest advances in 3D bioprinting for neural applications, including brain tumor modeling, neurodegenerative disease research, peripheral nervous system (PNS) repair, and cancer drug delivery. We discuss the principles and techniques of major bioprinting methods including extrusion-based, inkjet, laser-assisted, multimaterial, and coaxial bioprinting. The unique advantages are highlighted for engineering neural tissues and disease models. Special attention is given to the development of patient-specific brain tumor organoids, innovative scaffolds for neurodegenerative disease modeling, and bioprinted nerve guidance conduits for PNS regeneration. The review also addresses the challenges of vascularization, cell viability, and clinical translation, and explores future directions integrating 3D bioprinting with tissue engineering and digital technologies for personalized medicine. By bridging critical gaps in disease modeling and neural repair, 3D bioprinting holds the promise to revolutionize research and therapy for neurological and oncological disorders.
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