Latest Advances in Inflammatory Skin Disease

Abstract

Inflammatory skin disorders are chronic diseases that present with redness, itching, and plaques and occur due to the interaction between genetic and environmental factors. The immune basis of the disease involves the action of proinflammatory cytokines and overexpression of CD4+ and CD8+ T-cells.

Objective

To discuss the developments in chronic inflammatory disease pathogenesis and treatments using single-cell RNA sequencing and spatial transcriptomics.

Approach

Single-cell RNA analysis and spatial transcriptomics allow one to study a cell individually and identify the cell-to-cell differences and the mutations that can be found within individual cells in a pool. It aids in improved understanding of disease pathogenesis and helps identify the distinct mutations that arise in every disease which can be targeted for therapy. However, this technology is quite new and requires improvements on cost reduction and standardization of methods. Nevertheless, this approach has opened new avenues to studying disease pathogenesis and creating drugs targeting the active inflammatory pathway.

Conclusion

This review focuses on chronic inflammatory skin conditions like psoriasis, atopic dermatitis, acne, lichen planus, and alopecia.

This review provides insight into their pathogenesis and targeted therapy using the latest advances in the field of single-cell RNA sequencing and transcriptomics