Microneedles-mediated transdermal drug delivery techniques in modern medicine
DOI:
https://doi.org/10.60087/jklst.v4.n1.003Abstract
Transdermal Drug Delivery Systems (TDDS) present a transformative alternative to traditional drug administration methods,
addressing key challenges and revolutionizing the pharmaceutical industry. Despite the prevalence of traditional methods due
to their ease of administration and cost-effectiveness, they face limitations such as low bioavailability, gastrointestinal side
effects, patient non-adherence, and additional risks associated with invasive procedures. TDDS offer a near-painless
administration route that minimizes fluctuations in systemic drug exposure and enhances treatment adherence, especially in
low and middle-income countries. TDDS work by overcoming skin permeability barriers through modifications to drug
properties and the development of novel formulations and technologies, such as microneedles (MNs), which create micro-
channels in the skin for painless drug delivery. MNs have applications in treating various conditions, including HIV,
neurological disorders, diabetes, and cancer. Here in this review we discuss different types of MNs, such as dissolvable,
core–shell, and stimuli-responsive formulations and explore TDDS efficacy. Recent advancements, particularly in microneedle
technology, promise to revolutionize drug delivery methods, allowing for a more patient-friendly and effective means of
delivering necessary therapeutic agents.
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